To begin with your Ledger device, go to ledger.com/start. You'll be guided through the setup process, which includes downloading and installing Ledger Live, Ledger's official app for managing your crypto assets. Connect your Ledger device to your computer or mobile device and follow the on-screen instructions to configure it. This involves setting a secure PIN code and backing up your recovery phrase. Once set up, you can use Ledger Live to manage your cryptocurrencies, perform transactions, and monitor your portfolio. Ensure you keep your recovery phrase safe and private to protect your assets.